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The atypical journey of Primary Progressive Aphasia - Talk at the Dementia Society of Ottawa and Renfrew County

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Articles published by our team
Support and treatment
Carrier-Auclair, J., Lavoie, M., Tastevin, M., & Laforce Jr, R. (2024). Efficacy of acetylcholinesterase inhibitors in the logopenic variant of primary progressive aphasia. Dementia and Geriatric Cognitive Disorders, 10, 1‑12. – PDF Choi, Y.N.C., Martel-Sauvageau, V., Breton, M., Lavoie, M., Laforce Jr, R. & Bouvier, L. (2024). Efficacy of LSVT LOUD® on phonatory control and voice quality in patients with primary progressive apraxia of speech: Case studies. Brain Sciences, 14(5), 417. – PDF Monetta, L., Lavoie, M., Gagnon, M-F., Pelletier, R., Proulx, L., Duchesne, J., & Laforce Jr, R. (2024). Coconstruction d'un programme psychoéducatif d'information et de soutien pour les personnes vivant avec une aphasie primaire progressive et leurs proches. Revue canadienne d'orthophonie et d'audiologie, 48(3), 155‑167. – PDF Gallée, J., Cartwright, J., Grasso, S., Jokel, R., Lavoie, M., McGowan, E., Pozzebon, M., Beber, B.C., Duboisdindien, G., et al. (2024). Global perspectives on the management of primary progressive aphasia. Scientific Reports, 14(1), 19712. – PDF Volkmer, A., Alves, E.V., Bar-Zeev, H., Barbieri, E., Battista, P., Beales, A., Beber, B.C., Brotherhood, E., et al. (2025). An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings. Alzheimer's & Dementia, 21(1), e14362. – PDF
Assessment and diagnosis
Fernández-Romero, L., Morello-García, F., Laforce Jr, R. et al. (2024). Comparative accuracy of Mini-Linguistic State Examination, Addenbrooke's Cognitive Examination, and Depistage Cognitif de Quebec for the diagnosis of primary progressive aphasia. Journal of Alzheimer's Disease, 102(1), 67‑76. – Article on the Web Macoir, J., Légaré, A., & Lavoie, M. (2021). Contribution of the cognitive approach to language assessment to the differential diagnosis of Primary Progressive Aphasia. Brain Sciences, 11(6), 815. – PDF Macoir, J., Laforce Jr, R. & Lavoie, M. (2024). The impact of phonological short-term memory impairment on verbal repetition in the logopenic variant of primary progressive aphasia. Neuropsychology, development, and cognition, 31(4), 723‑741. – Article on the Web Hasanovic, A., Macoir, J., Sanfaçon-Verret, A., & Monetta, L. (2025). The functional origin of oral word production deficits in the logopenic variant of Primary Progressive Aphasia: A systematic review. Brain Sciences, 15(2), 111. – PDF Wu, F., Dallaire-Théroux, C., Michaud, É., Bergeron, F., Lavoie, M., Soucy, J.P., Dirani, A., & Laforce, R. (2025). Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations. Journal of Alzheimer's Disease. – Article on the Web
Disease progression
de la Sablonnière, J., Tastevin, M., Lavoie, M., & Laforce Jr, R. (2021). Longitudinal changes in cognition, behaviours, and functional abilities in the three main variants of Primary Progressive Aphasia: A literature review. Brain Sciences, 11(9), 1209. – PDF Tastevin, M., Lavoie, M., de la Sablonnière, J., Carrier-Auclair, J., Laforce, Jr, R. (2021). Survival in the three common variants of Primary Progressive Aphasia: A retrospective study in a tertiary memory clinic. Brain Sciences, 11(9), 1113. – PDF
Other
Canet, G., Da Gama Monteiro, F., Rocaboy, E., Diego-Diaz, S., Khelaifia, B., Godbout, K., et al. (2025). Sleep-wake variation in body temperature regulates tau secretion and correlates with CSF and plasma tau. The Journal of Clinical Investigation, 35(7), e182931. – PDF

Publications on cognitive health

• Dementia Prevention - 12 Modifiable Risk Factors And Their Means Of Prevention
• U.S. National Institute on Aging - Cognitive Health and Older Adults

Tips for patients and relatives

• Non fluent/agrammatic PPA
• Logopenic PPA
• Semantic PPA

I am looking for a health professional in my area

Specialized clinic

Quebec City Area

La Clinique Interdisciplinaire de Mémoire (CIME) du CHU de Québec : https://www.chudequebec.ca/patient/maladies,-soins-et-services/m-informer-sur-les-soins-et-services/clinique-interdisciplinaire-de-memoire-(cime).aspx

Montreal Area

Institut Neurologique de Montréal - Dr. Simon Ducharme
3801 rue University, Montréal QC H3A 2B4
Tel.: 514-398-1911 | Fax : 514-498-2745

Clinique d'investigation gériatrique ambulatoire (CIGA)
135 rue Claude David, Repentigny QC J6A 1N6
Tel.: 450-470-2656 | Fax : 450-470-2651

Speech therapy

Quebec City Area

La Clinique d'orthophonie de l'Université Laval : https://www.fmed.ulaval.ca/faculte-et-reseau/a-propos-de-la-faculte/departements/departement-de-readaptation/cliniques-universitaires/la-clinique-en-orthophonie/

Bibliographical references

Bergeron D, Rabinovici G, Gorno-Tempini ML, Seeley W, Miller BL, Pijnenburg Y, van der Flier W, van Berckel B, Scheltens P, Groot C, Rohrer JD, Warren JD, Schott J, Fox N, Sanchez-Valle R, Grau-Riviera O, Hodges J, Leyton C, Piguet O, Rogalki E, Mesulam M, Koric L, Kristensen N, Pariente J, Dickerson B, Mackenzie I, Hsiung R, Belliard S, Wolk D, Grossman M, Jones M, Harris J, Snowden J, Chrem-Mendez P, Calandri I, Amengual A, Magnin E, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Keith K, Masselis M, Black SE, Matias-Guiu J, Cabrera-Martin M, Paquet C, Dumuirger J, Teichmann M, Rowe C, Villemagne V, Vandenberghe R, Granadillon E, Mendez M, Meyer P, Frings L, Sarazin M, Dubois B, Won Seo S, Grimmer T, Frederiksen KS, Sanchez-Juan P, Chételat G, Jansen W, Laforce RJr, Visser PJ, Ossenkoppele R. (2018). Prevalence of amyloid‑? pathology in variants of primary progressive aphasia. Annals of neurology. 84(5): 729‑740.

Gorno-Tempini, M.L., Hillis, A.E., Weintraub, S. et al. Neurology Mar 2011, 76 (11) 1006‑1014; doi: 10.1212/WNL.0b013e31821103e6

Leyton CE, Villemagne VL, Savage S, Pike KE, Ballard KJ, Piguet O, Burrell JR, Rowe CC, Hodges JR. Subtypes of progressive aphasia: application of the International Consensus Criteria and validation using β-amyloid imaging. Brain. 2011 Oct;134(Pt 10):3030‑43. doi: 10.1093/brain/awr216. Epub 2011 Sep 9.

Marshall, C.R., Hardy, C.J.D., Volkmer, A. et al. J Neurol (2018) 265: 1474. https://doi.org/10.1007/s00415-018-8762-6

Mesulam, M.M. Primary progressive aphasia. Ann Neurol. 2001; 49(4): 425‑432.

Courtemanche, Hélène. Les aphasies progressives primaire. - Cours en ligne

Grossman, M. Primary progressive aphasia: clinicopathological correlations. Nat Rev Neurol 6, 88‑97 (2010).

Mesulam MM, Rogalski EJ, Wieneke C, et al. Primary progressive aphasia and the evolving neurology of the language network. Nat Rev Neurol. 2014;10(10):554‑569. doi:10.1038/nrneurol.2014.159

Aphasia.org : https://www.aphasia.org/aphasia-resources/primary-progressive-aphasia/